Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils
نویسندگان
چکیده
منابع مشابه
Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils.
Interleukin-9 (IL-9) has been implicated in the pathogenesis of allergic disorders. To examine the interaction between IL-9 and eosinophils, we evaluated mature peripheral blood eosinophils for their expression of the specific alpha-subunit of the IL-9 receptor (IL-9R-alpha). The expression of IL-9R-alpha by human eosinophils was detected at the messenger RNA (mRNA) and protein levels by revers...
متن کاملIMMUNOBIOLOGY Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils
Interleukin-9 (IL-9) has been implicated in the pathogenesis of allergic disorders. To examine the interaction between IL-9 and eosinophils, we evaluated mature peripheral blood eosinophils for their expression of the specific a-subunit of the IL-9 receptor (IL-9R–a). The expression of IL-9R–a by human eosinophils was detected at the messenger RNA (mRNA) and protein levels by reverse transcript...
متن کاملAnalysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils.
We and other groups have previously shown that interleukin-5 (IL-5) maintained the viability of mature eosinophils in an in vitro liquid culture system. Mature eosinophils did not proliferate but their survival was maintained in the presence of IL-5. Using this culture system, we investigated the mechanism of IL-5-mediated survival. In the absence of human IL-5 (hIL-5) mature eosinophils succum...
متن کاملInterleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques.
OBJECTIVE Interleukin (IL)-33 is the most recently described member of the IL-1 family of cytokines and it is a ligand of the ST2 receptor. While the effects of IL-33 on the immune system have been extensively studied, the properties of this cytokine in the cardiovascular system are much less investigated. Methods/Results- We show here that IL-33 promoted the adhesion of human leukocytes to mon...
متن کاملInterleukin-33 in human gliomas: Expression and prognostic significance
Interleukin-33 (IL-33) is a nuclear and pleiotropic cytokine with regard to its cellular sources and its actions. IL-33 is involved in the pathogenesis of brain diseases. Several factors account for the tumorigenicity of human gliomas, including cytokines and their receptors. The present study assessed the expression and prognostic significance of IL-33 in human astroglial brain tumors. Protein...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2008
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2008.82